The explosion in popularity of GLP-1 agonists as a primary agent for weight loss has transformed the field of obesity medicine in recent years. Whether professionally for or against the use of GLP-1 medications, GLP-1s are undoubtedly here to stay. As a result, psychotherapists are finding themselves engaged in ardent discussion with clients of all body sizes who are seeking psychological advice, approval, or simply informing their therapists that they have already begun GLP-1 treatment as prescribed by their physician or an online platform. In this timely and impactful presentation, Dr. Anné Zeig will offer a comprehensive and integrated approach to working with individuals using GLP-1s that incorporates research and her expertise in the interrelated areas of complex trauma, eating disorders, and emotion-driven issues of weight. Amongst the content discussed, Dr. Anné Zeig will emphasize the need for informed assessment, conceptualization and treatment of current and past eating disorder dynamics, chronic dieting behavior, unresolved complex trauma, and the development of a healthy relationship with food and weight based on a positive core relationship with body, emotions, Self, and Others. Additionally, Dr. Anné Zeig will illustrate how unresolved complex trauma obstructs the efficacy of current first line models of treatment as well as her hypothesis that it also negatively impacts the efficacy of long-term GLP-1 success.