False Failures: Knowing When to Hang Tight
(Focus on recognizing pseudo–treatment failure and avoiding premature therapy changes. Discuss optimization strategies, including extended induction with upadacitinib when appropriate, and appropriate use and dose optimization of anti-TNF therapies before declaring true failure. Address common misconceptions around early loss of response, inadequate dosing, and timing of assessment, emphasizing when to persist, optimize, or pivot based on clinical and objective data.)