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The Official Meeting of Oncology Learning Network
David S. Siegel, MD, PhD, is one of the nation’s foremost authorities on multiple myeloma (a blood cancer). His research has almost exclusively focused on multiple myeloma, Waldenstrom’s macroglobulinemia, and AL amyloidosis, and has been published in many leading medical journals, including Nature, New England Journal of Medicine, Blood, and Journal of Clinical Oncology.
He served as the lead investigator of the pivotal phase IIb study involving 30 cancer centers in North America that led to the U.S. Food and Drug Administration’s fast-track approval of Kyprolis (carfilzomib) for recurrent multiple myeloma. Dr. Siegel is one of 11 investigators nationwide who brought Velcade (bortezomib) to multiple myeloma patients through his clinical trials showing that this medication slows and halts the progression of multiple myeloma. He has also been involved in clinical trials that led to the approval of Thalomid (thalidomide), Revlimid (lenalidomide), Pomalyst (pomalidomide), Ninlaro (Ixazomib), Empliciti (elotuzumab), and Farydak (panobinostat).
Dr. Siegel is founding Director of the Multiple Myeloma Institute. He and his team collaborate with other scientists and clinical researchers to pioneer critical therapies to treat patients with multiple myeloma. Dr. Siegel has also led John Theurer Cancer Center’s development of a program to offer CAR T-cell therapy to patients with multiple myeloma. With this immunotherapy, T cells are removed from the patient, genetically modified, multiplied, and returned to the patient to find and kill myeloma cells.