Illicitly Manufactured Fentanyl: Examining Current Trends in Supply, Co-use with Stimulants, and Overdose

Session Description: First, we illustrate that urine drug test (UDT) results tightly correlate with trends in fentanyl-related overdose deaths. Second, we explore changes in the co-detection of prescription opioids, heroin, methamphetamine, and cocaine in fentanyl-positive specimens. Lastly, we provide insight into recent trends in polysubstance use among people who use fentanyl. This information will instruct clinicians as to the most prevalent illicitly manufactured substances and trends throughout our nation over time, including lasting effects from COVID-19. Further, clinicians can expect a case-based approach which will be used to develop skills to interpret UDT results and navigate scenarios involving polysubstance use. This presentation will be broken into 2 sections: 1. An in-depth discussion of the 2024 national illicitly manufactured fentanyl changes and co-positivity trends 2. Illicit opioid and stimulant drug trends and percent changes in positivity of these substances over time (including before and after the declaration of COVID-19 as a national emergency).