Kanhaiya Singh

Dr. Kanhaiya Singh is an Associate Professor at the Department of Surgery, University of Pittsburgh. Dr. Singh received his doctoral degree in Biotechnology from Banaras Hindu University, India. Prior to joining University of Pittsburgh, Dr. Singh served as an Assitant Professor at Indiana University. His research focus is on epigenetic mechanisms of gene expression during diabetic vasculopathy and includes single-cell transcriptomics and single-cell ATAC sequencing approaches to investigate the molecular pathways that are compromised. His laboratory is also investigating the epigenetic mechanisms such as DNA methylation as a proxy for abnormal gene–environmental interactions in diabetic ischemic wounds. Current line of study aims to develop a simple and point of care approach to achieve targeted epigenetic editing of adult diabetic ischemic tissue in vivo. To that end, his team is employing Tissue Nanotransfection (TNT) technology as a delivery platform to administer combination gene therapy for diabetic ischemic tissue rescue. This research is funded through peer-reviewed grants from Department of Defense (DoD) and NIH-NIDDK. Dr. Singh has authored more than 50 peer reviewed publications. Dr Singh has been an Editorial Boards peer reviewed journals such as Scientific Reports, Plos One, Frontiers in Endocrinology and Heliyon. In this role, he has edited more than 200 publications and 4 special issues. He serves as active member of Wound Healing Society and American Diabetes Association.

Dr. Luis Garza is a Professor & Daniel Nathans Scholar at the Johns Hopkins School of Medicine Department of Dermatology. He is a physician scientist who sees Dermatology patients and also conducts research on skin disease. His laboratory is interested in regenerative medicine, innate immunity and the disease Hidradenitis Suppurativa. Besides directing the Hidradenitis Suppurative clinic and conducting research, Dr. Garza is also committed to teaching and is the PI/PD of an NIH T32. Finally, he also works as a Vice-Chair of the department of Dermatology.

Dr. Dana T. Graves is Professor in the Department of Periodontics and Vice Dean for Scholarship and Research at the University of Pennsylvania School of Dental Medicine, where he also directs the Doctor of Science in Dentistry program. Dr. Graves received his DDS degree from Columbia University and his DMSc degree in Oral Biology and Certificate in Periodontics from Harvard University. His research focus includes the cellular and molecular mechanisms that regulate normal and diabetic wound healing, with particular emphasis on how diabetes-induced inflammation alters epithelial, fibroblast, and mesenchymal responses. His laboratory has defined important roles for FOXO1, TNF, and related inflammatory pathways in impaired diabetic tissue repair and has used genetic models, and single-cell transcriptomics to identify mechanisms and potential therapeutic targets. This research is supported by multiple NIH R01 grants. Dr. Graves has authored more than 250 peer-reviewed publications and has received research honors including the IADR Distinguished Scientist Award in Basic Research in Periodontal Disease, the Wound Healing Research Scholarship Award, and the IADR/PRG Award in Regenerative Periodontal Medicine. He serves as an Associate Editor of the Journal of Dental Research.

Dr. Kirsner is Chairman, Tenured Professor and the endowed Harvey Blank Chair in the Dr. Phillip Frost Dermatology in the Department of Dermatology and Cutaneous Surgery and Professor of Public Health Sciences at the University of Miami Miller School of Medicine. He is Chief of Dermatology at the University of Miami Hospital and Clinics and Jackson Memorial Hospital and directs the University of Miami Hospital Wound Center. Dr. Kirsner received his undergraduate degree from Texas A&M University, his medical degree from the University of Miami and a PhD in epidemiology from the University of Miami, after he completed his clinical training. His clinical training included internal medicine, a clinical and research fellowship in wound healing and dermatology at the University of Miami. His research interests include Wound Healing and Skin Cancer Epidemiology. Dr. Kirsner serves as one of 3 academic editors for the journal Wound Repair and Regeneration and on the editorial boards for several other journals in dermatology and wound healing. Dr. Kirsner serves in national leadership positions in both Wound Healing and Dermatology, including serving as past Vice President of the American Academy of Dermatology and is currently President of the Wound Healing. In addition to career development awards, foundation, industry sponsored funding and CDC funding, he currently leads or is part of several NIH funded grants. Independent of books, book chapters and abstracts, he has published over 650 articles.

Dr. Kanhaiya Singh is an Associate Professor at the Department of Surgery, University of Pittsburgh. Dr. Singh received his doctoral degree in Biotechnology from Banaras Hindu University, India. Prior to joining University of Pittsburgh, Dr. Singh served as an Assitant Professor at Indiana University. His research focus is on epigenetic mechanisms of gene expression during diabetic vasculopathy and includes single-cell transcriptomics and single-cell ATAC sequencing approaches to investigate the molecular pathways that are compromised. His laboratory is also investigating the epigenetic mechanisms such as DNA methylation as a proxy for abnormal gene–environmental interactions in diabetic ischemic wounds. Current line of study aims to develop a simple and point of care approach to achieve targeted epigenetic editing of adult diabetic ischemic tissue in vivo. To that end, his team is employing Tissue Nanotransfection (TNT) technology as a delivery platform to administer combination gene therapy for diabetic ischemic tissue rescue. This research is funded through peer-reviewed grants from Department of Defense (DoD) and NIH-NIDDK. Dr. Singh has authored more than 50 peer reviewed publications. Dr Singh has been an Editorial Boards peer reviewed journals such as Scientific Reports, Plos One, Frontiers in Endocrinology and Heliyon. In this role, he has edited more than 200 publications and 4 special issues. He serves as active member of Wound Healing Society and American Diabetes Association.

Crystal Murray Holmes, DPM, is a podiatry specialist in Ann Arbor, Michigan. She graduated from Kent State College of Podiatric Medicine. Dr. Holmes is currently a Clinical Associate Professor with University of Michigan Health System. She founded the Michigan Medicine Podiatry program in 2006 and still serves as the Program Director. She also has an active role in the training program for the University of Michigan Podiatry Research Fellowship in Limb Preservation, Wound Care, and Diabetes Related Lower Extremity Complications. The fellowship involves emphasis on research and patient populations at risk for limb loss. Dr. Holmes has had numerous leadership roles in national and international organizations such as chairperson on the scientific meeting planning committees at the International Working Group Diabetic Foot: Charcot, American Podiatric Medical Association and American Diabetes Association, and is a past president of the Michigan Podiatric Medical Association. She has research interest in diabetes limb preservation and has grant funding from the NIH/NIDDK and serves as a principle investigator in the Diabetic Foot Consortium.

Kellen Chen, PhD, is an assistant research professor in the Department of Surgery and Department of Biomedical Engineering at the University of Arizona, College of Medicine – Tucson. He previously received his PhD in Biomedical Engineering from the University of Virginia and earned his B.S. in Bioengineering from the University of California, Berkeley. Dr. Chen completed his postdoctoral research fellowship at Stanford University.

Dr. Chen studies therapies to improve outcomes after injury, skin grafting, chronic wound development, biomedical device implantation, and more. Among these many research avenues, Dr. Chen is particularly interested in the molecular and cellular drivers of fibrosis and regeneration across all organ systems, and he previously studied healing after myocardial infarction or Achilles tendon injuries. He is also currently working on obtaining FDA approval for a clinical trial to study pharmacological inhibition of mechanical signaling to accelerate healing of deep dermal injury.

Dr. Chen has co-authored over 50 peer-reviewed publications and three book chapters, including first author publications in journals such as the Science Translational Medicine, Nature Communications, and PNAS. He has received a variety of awards, including the First Place Young Investigator’s Award from the Wound Healing Society.

Crystal Murray Holmes, DPM, is a podiatry specialist in Ann Arbor, Michigan. She graduated from Kent State College of Podiatric Medicine. Dr. Holmes is currently a Clinical Associate Professor with University of Michigan Health System. She founded the Michigan Medicine Podiatry program in 2006 and still serves as the Program Director. She also has an active role in the training program for the University of Michigan Podiatry Research Fellowship in Limb Preservation, Wound Care, and Diabetes Related Lower Extremity Complications. The fellowship involves emphasis on research and patient populations at risk for limb loss. Dr. Holmes has had numerous leadership roles in national and international organizations such as chairperson on the scientific meeting planning committees at the International Working Group Diabetic Foot: Charcot, American Podiatric Medical Association and American Diabetes Association, and is a past president of the Michigan Podiatric Medical Association. She has research interest in diabetes limb preservation and has grant funding from the NIH/NIDDK and serves as a principle investigator in the Diabetic Foot Consortium.

Brian Schmidt, DPM is an Associate Professor of Internal Medicine in the Division of Metabolism, Endocrinology, and Diabetes at the University of Michigan Medical School. He was raised in Michigan and completed his undergraduate studies at the University of Michigan. After undergrad program, Dr. Schmidt proceeded to Rosalind Franklin University of Medicine and Science and graduated summa cum laude as a Doctor of Podiatric Medicine (DPM).

Dr. Schmidt completed his Podiatric Medicine and Surgery Residency with Reconstructive Rearfoot and Ankle certification at Yale University. Dr. Schmidt is board certified by the American Board of Podiatric Medicine (ABPM). He has published numerous peer-reviewed manuscripts, book chapters, and is a leading expert in diabetic foot.

Dr. Schmidt has applied his clinical interest to translational research to better understand and promote diabetic foot ulcer healing and limb salvage through science. He is actively supported in his research by the National Institute of Health (NIH), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and industry.

Dr. Schmidt is an active member in multiple medical societies and holds leadership roles.

Dr. Kanhaiya Singh is an Associate Professor at the Department of Surgery, University of Pittsburgh. Dr. Singh received his doctoral degree in Biotechnology from Banaras Hindu University, India. Prior to joining University of Pittsburgh, Dr. Singh served as an Assitant Professor at Indiana University. His research focus is on epigenetic mechanisms of gene expression during diabetic vasculopathy and includes single-cell transcriptomics and single-cell ATAC sequencing approaches to investigate the molecular pathways that are compromised. His laboratory is also investigating the epigenetic mechanisms such as DNA methylation as a proxy for abnormal gene–environmental interactions in diabetic ischemic wounds. Current line of study aims to develop a simple and point of care approach to achieve targeted epigenetic editing of adult diabetic ischemic tissue in vivo. To that end, his team is employing Tissue Nanotransfection (TNT) technology as a delivery platform to administer combination gene therapy for diabetic ischemic tissue rescue. This research is funded through peer-reviewed grants from Department of Defense (DoD) and NIH-NIDDK. Dr. Singh has authored more than 50 peer reviewed publications. Dr Singh has been an Editorial Boards peer reviewed journals such as Scientific Reports, Plos One, Frontiers in Endocrinology and Heliyon. In this role, he has edited more than 200 publications and 4 special issues. He serves as active member of Wound Healing Society and American Diabetes Association.

Kellen Chen, PhD, is an assistant research professor in the Department of Surgery and Department of Biomedical Engineering at the University of Arizona, College of Medicine – Tucson. He previously received his PhD in Biomedical Engineering from the University of Virginia and earned his B.S. in Bioengineering from the University of California, Berkeley. Dr. Chen completed his postdoctoral research fellowship at Stanford University.

Dr. Chen studies therapies to improve outcomes after injury, skin grafting, chronic wound development, biomedical device implantation, and more. Among these many research avenues, Dr. Chen is particularly interested in the molecular and cellular drivers of fibrosis and regeneration across all organ systems, and he previously studied healing after myocardial infarction or Achilles tendon injuries. He is also currently working on obtaining FDA approval for a clinical trial to study pharmacological inhibition of mechanical signaling to accelerate healing of deep dermal injury.

Dr. Chen has co-authored over 50 peer-reviewed publications and three book chapters, including first author publications in journals such as the Science Translational Medicine, Nature Communications, and PNAS. He has received a variety of awards, including the First Place Young Investigator’s Award from the Wound Healing Society.

Dr. Kanhaiya Singh is an Associate Professor at the Department of Surgery, University of Pittsburgh. Dr. Singh received his doctoral degree in Biotechnology from Banaras Hindu University, India. Prior to joining University of Pittsburgh, Dr. Singh served as an Assitant Professor at Indiana University. His research focus is on epigenetic mechanisms of gene expression during diabetic vasculopathy and includes single-cell transcriptomics and single-cell ATAC sequencing approaches to investigate the molecular pathways that are compromised. His laboratory is also investigating the epigenetic mechanisms such as DNA methylation as a proxy for abnormal gene–environmental interactions in diabetic ischemic wounds. Current line of study aims to develop a simple and point of care approach to achieve targeted epigenetic editing of adult diabetic ischemic tissue in vivo. To that end, his team is employing Tissue Nanotransfection (TNT) technology as a delivery platform to administer combination gene therapy for diabetic ischemic tissue rescue. This research is funded through peer-reviewed grants from Department of Defense (DoD) and NIH-NIDDK. Dr. Singh has authored more than 50 peer reviewed publications. Dr Singh has been an Editorial Boards peer reviewed journals such as Scientific Reports, Plos One, Frontiers in Endocrinology and Heliyon. In this role, he has edited more than 200 publications and 4 special issues. He serves as active member of Wound Healing Society and American Diabetes Association.