In this authoritative translational review published in The American Journal of Psychiatry, leading researchers synthesize cutting-edge evidence on how cannabis use impacts adolescent neurodevelopment and behavior. Leveraging longitudinal human neuroimaging alongside rigorously controlled animal models, the article highlights compelling associations between early and frequent cannabis exposure, especially high-THC products, and disruptions in critical brain maturation processes that underlie cognition and emotional regulation. 

The Guardian’s December 28, 2025 analysis highlights an emerging public health contributor to the historic decline in U.S. overdose deaths: expanded Crisis Intervention Training (CIT) for law enforcement, emphasizing evidence-informed, compassionate responses to substance use disorders. Since late 2023, national overdose mortality has fallen, reflecting broader progress seen in provisional CDC data showing significant decreases in drug overdose fatalities.