WHS Session C: Engineering Regeneration: Insights from Novel and Comparative Wound Healing Models

The ideal response to injury is regeneration, but mature tissues typically have limited capacity for true regeneration. A better understanding of the mechanisms by which tissue regeneration occurs, including how cell-ECM interactions and mechanosignaling influence this process, could lead to new approaches to promote regenerative healing. This session will highlight new work on engineered biomimetic model development and detailed characterization of ECM-driven responses of cells from regenerative species to uncover novel mechanistic information about tissue regeneration.

Reverse Engineering of Wound Healing: Lessons from Microtissue Models
Jeroen Eyckmans, PhD

Fibroblasts from Highly Regenerative Mammals Evade Biomechanical Cues to Drive Proliferation
Robyn Allen, VMD, PhD