Chronic Itch Update: Emerging Mechanisms and New Therapeutic Targets

Chronic itch is increasingly understood as a complex neuroimmune process with distinct pathways, triggers, and treatment targets. This session reviews emerging mechanisms in pruritus, including inflammatory signaling, neural sensitization, barrier dysfunction, and systemic contributors. The discussion will connect evolving science with therapeutic development, helping clinicians better classify itch, identify underlying drivers, and consider new or emerging treatment approaches.