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Faculty

David Irwin

MD
Associate Professor
University of Pennsylvania

Dr. Irwin is a physician-scientist who completed undergraduate education at Drew University and medical school at Drexel College of Medicine in Philadelphia, where he also completed neurology residency as chief resident. He had postdoctoral training in neurodegeneration at Penn, where he also had clinical training in cognitive and behavioral neurology. He has the unique perspective of performing both detailed longitudinal clinical assessments in natural history studies, as well as postmortem examination of human brain tissue, in many of the same individual patients. Dr. Irwin co-directs the Penn Frontotemporal Degeneration Center and LBDA Research Center of Excellence at Penn. Dr. Irwin’s lab combines novel image analysis approaches with gold-standard histopathology and molecular techniques to integrate measures of postmortem neuropathology with antemortem biomarker data. The overall goal of this approach is to identify therapeutic targets and markers of disease progression that can serve as endpoints in treatment trials.

2026 Sessions

Beyond Alzheimer’s: Navigating the Spectrum of Dementia

While Alzheimer’s disease remains the most recognized cause of cognitive decline, clinicians increasingly encounter patients whose symptoms reflect a broader spectrum of neurodegenerative, vascular, and mixed dementias. Accurate differentiation among dementia subtypes is essential for timely diagnosis, management, counseling, and optimization of patient and caregiver outcomes. This session will provide an evidence-based overview of the major dementia syndromes beyond Alzheimer’s disease. Through discussion of clinical presentations, diagnostic considerations, biomarkers, neuroimaging findings, and management strategies, participants will gain practical tools to recognize distinguishing features and navigate the complexities of dementia care across diverse patient populations.

Presenter

Friday, December 04 2:30–3:30 PM
Room Windsong 1-4
Faculty

David Irwin

MD
Associate Professor
University of Pennsylvania

Dr. Irwin is a physician-scientist who completed undergraduate education at Drew University and medical school at Drexel College of Medicine in Philadelphia, where he also completed neurology residency as chief resident. He had postdoctoral training in neurodegeneration at Penn, where he also had clinical training in cognitive and behavioral neurology. He has the unique perspective of performing both detailed longitudinal clinical assessments in natural history studies, as well as postmortem examination of human brain tissue, in many of the same individual patients. Dr. Irwin co-directs the Penn Frontotemporal Degeneration Center and LBDA Research Center of Excellence at Penn. Dr. Irwin’s lab combines novel image analysis approaches with gold-standard histopathology and molecular techniques to integrate measures of postmortem neuropathology with antemortem biomarker data. The overall goal of this approach is to identify therapeutic targets and markers of disease progression that can serve as endpoints in treatment trials.
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