Panel 1. Studying the Patients We Actually Treat: The Role of Real-World Evidence

This panel reviews recent RWE initiatives from WCCC’s Natural History Project, including highlights from three forthcoming publications that characterize patient complexity, wound trajectories, and outcomes in routine practice. Panelists will also discuss how these data inform endpoint selection, risk adjustment, and trial design. Panelists will discuss what these findings mean for clinical practice, trial design, regulatory and payer decision-making, and identify priority areas for methodological alignment and collaborative next steps to translate realworld data into measurable improvements.