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Explore postoperative treatment strategies following liver resection, comparing the role of adjuvant hepatic arterial infusion (HAI) therapy with systemic adjuvant chemotherapy. Faculty will examine available evidence on recurrence risk reduction, survival outcomes, and toxicity profiles associated with each approach. The discussion will address practical considerations influencing treatment choice and provide new insight into whether adjuvant HAI offers added benefit over standard systemic chemotherapy. Adjuvant HAI therapy has a meaningful role following liver resection compared with adjuvant systemic chemotherapy alone. Faculty will review clinical evidence demonstrating improved hepatic disease control and survival outcomes with HAI in selected patients, guiding learners through scenarios in which adjuvant HAI may optimize outcomes.