pMMR/MSS Disease Demands a Different Strategy: Targeted Combinations and Molecular Subtyping Over Reflexive IO

This session will explore first-line treatment strategies for advanced or recurrent endometrial cancer, examining whether chemo-immunotherapy should be broadly applied or tailored based on molecular subtype. Faculty will review key clinical trial data, including outcomes by mismatch repair status, and discuss biomarker-driven decision-making, toxicity considerations, and real-world implementation. Participants will gain practical insight into optimizing treatment selection in a rapidly evolving landscape. This discussion will argue for a more tailored approach in pMMR/MSS disease. Faculty will examine the comparatively modest benefit of immunotherapy in this subgroup and emphasize the role of targeted combinations and molecular subtyping to guide treatment. Practical considerations around patient selection, sequencing, and emerging data will be addressed.