Established HER2-Targeted Therapy

This session will examine first-line treatment strategies for HER2-positive gastroesophageal cancer, comparing established HER2-targeted regimens with emerging next-generation combinations. Faculty will review key clinical data, biomarker considerations, and mechanisms of resistance, while discussing practical factors that influence treatment selection and sequencing. Participants will gain insight into optimizing care in a rapidly evolving landscape. This discussion will highlight established HER2-targeted regimens as the foundation of first-line treatment. Faculty will review pivotal data supporting chemotherapy plus trastuzumab-based approaches, with or without immunotherapy, focusing on survival outcomes, safety, and broad clinical applicability. Practical guidance on patient selection and toxicity management will be emphasized.