Faculty

Sarah Premji

MD
Assistant Director, Breast Cancer Research
Sarah Cannon Research Institute

Dr. Sarah Premji joined Sarah Cannon Research Institute as Assistant Director of Breast Cancer Research and Medical Oncologist at Sarah Cannon Research Institute Oncology Partners in September 2025.

Dr. Premji completed medical school at the Medical College of Georgia, residency at Baylor College of Medicine and fellowship at Mayo Clinic. Her research interest is breast oncology therapeutics with a focus on patient reported outcomes and treatment toxicity in clincial trials. She attended the prestigous ASCO/AACR Methods in Clinical Cancer Research, formerly known as Vail Workshop and was awarded a ASCO Concur Cancer Young Investigator Award in 2025. While in fellowship, she was awarded Minnesota Society of Clinical Oncology's "outstanding fellow" award, was recognised at San Antonio Breast Cancer Symposium for a clinical scholar award and received a Mayo Clinic small grant award. Dr. Premji was also awarded scholarships to attend numerous workshops including the Duke Southeastern Fellows Research Retreat, NCCN Oncology Fellows Program, Lynn Sage Symposium, Translational Breast Cancer Research Consortium and Alliance.

2026 Sessions

General Session

Oral SERDs in Breast Cancer: They’re All the Same: Yes vs No

This debate will examine the evolving role of oral selective estrogen receptor degraders (SERDs) in breast cancer and address the question of whether these agents are truly...

  • Moderator
    • Kelly McCann, MD, PhD
  • Presenter
    • Sarah Premji, MD
    • Seth Wander, MD, PhD
Breast Cancers

Yes

This debate will examine the evolving role of oral selective estrogen receptor degraders (SERDs) in breast cancer and address the question of whether these agents are truly interchangeable. Compare differences in mechanism of action, clinical efficacy, resistance profiles, and safety across available and emerging oral SERDs. Speakers will highlight implications for patient selection and sequencing in hormone receptor-positive disease and provide expert insight into how nuanced differences among oral SERDs may influence real-world treatment decisions.

Faculty will review shared mechanisms of action, class-wide efficacy data, and common safety profiles across available, largely comparable therapeutic agents. The discussion will address whether differences among oral SERDs translate into meaningful distinctions in clinical practice, and participants will gain insight into the rationale for viewing oral SERDs as a broadly similar therapeutic class in hormone receptor-positive breast cancer.

Presenter

Saturday, March 14 10:25–10:45 AM
Room Royal Ballroom 1
Breast Cancers
Faculty

Seth Wander

MD, PhD
Assistant Professor of Medicine
Harvard Medical School, Massachusetts General Hospital

Dr. Wander is a medical oncologist at the Massachusetts General Hospital with a clinical and translational research interest in breast cancer and cancer genomics. He serves as the Director of Translational Research for the Breast Oncology Program, where he leads a multidisciplinary team focused upon leveraging genetic and molecular sequencing results to understand how cancers become resistant to standard therapies in order to develop novel, personalized treatment strategies. Dr. Wander has published more than seventy peer-reviewed manuscripts in the field of precision medicine and continues to present educational sessions and original research nationally and internationally related to drug resistance and the development of personalized therapy for breast cancer. He is an Assistant Professor of Medicine at Harvard Medical School and remains engaged in teaching medical students, residents, and fellows. He was a recipient of the 2017 Dana-Farber Cancer Institute Wong Family Translational Research Award and a 2018 recipient of the American Society of Clinical Oncology Young Investigator Award. As the Director of Precision Medicine in the Termeer Center for Targeted Therapies, he leads efforts across the MGH Cancer Center to promote novel and innovative research leveraging emerging genetic sequencing technologies to both understand resistance to cancer therapies and inform the design of new clinical trials. Dr. Wander's research has helped to shape our understanding of drug resistance in metastatic breast cancer, and he continues to lead a variety of clinical trials, across all phases of drug development, focused upon developing new, personalized treatment options for patients with breast cancer.

No

This debate will examine the evolving role of oral selective estrogen receptor degraders (SERDs) in breast cancer and address the question of whether these agents are truly interchangeable. Compare differences in mechanism of action, clinical efficacy, resistance profiles, and safety across available and emerging oral SERDs. Speakers will highlight implications for patient selection and sequencing in hormone receptor-positive disease and provide expert insight into how nuanced differences among oral SERDs may influence real-world treatment decisions.

Our presenters will examine differences in pharmacology, potency, resistance profiles, and clinical trial outcomes among available and emerging agents, discussing how these distinctions may influence patient selection, sequencing, and combination strategies. Delve into the clinical relevance for patients of heterogeneity within the oral SERD class.

Presenter

Saturday, March 14 10:45–11:05 AM
Room Royal Ballroom 1
Breast Cancers
Faculty

Sarah Premji

MD
Assistant Director, Breast Cancer Research
Sarah Cannon Research Institute

Dr. Sarah Premji joined Sarah Cannon Research Institute as Assistant Director of Breast Cancer Research and Medical Oncologist at Sarah Cannon Research Institute Oncology Partners in September 2025.

Dr. Premji completed medical school at the Medical College of Georgia, residency at Baylor College of Medicine and fellowship at Mayo Clinic. Her research interest is breast oncology therapeutics with a focus on patient reported outcomes and treatment toxicity in clincial trials. She attended the prestigous ASCO/AACR Methods in Clinical Cancer Research, formerly known as Vail Workshop and was awarded a ASCO Concur Cancer Young Investigator Award in 2025. While in fellowship, she was awarded Minnesota Society of Clinical Oncology's "outstanding fellow" award, was recognised at San Antonio Breast Cancer Symposium for a clinical scholar award and received a Mayo Clinic small grant award. Dr. Premji was also awarded scholarships to attend numerous workshops including the Duke Southeastern Fellows Research Retreat, NCCN Oncology Fellows Program, Lynn Sage Symposium, Translational Breast Cancer Research Consortium and Alliance.

No

This debate will examine the evolving role of oral selective estrogen receptor degraders (SERDs) in breast cancer and address the question of whether these agents are truly interchangeable. Compare differences in mechanism of action, clinical efficacy, resistance profiles, and safety across available and emerging oral SERDs. Speakers will highlight implications for patient selection and sequencing in hormone receptor-positive disease and provide expert insight into how nuanced differences among oral SERDs may influence real-world treatment decisions.

Our presenters will examine differences in pharmacology, potency, resistance profiles, and clinical trial outcomes among available and emerging agents, discussing how these distinctions may influence patient selection, sequencing, and combination strategies. Delve into the clinical relevance for patients of heterogeneity within the oral SERD class.

Presenter

Saturday, March 14 10:45–11:05 AM
Room Royal Ballroom 1
Breast Cancers
Faculty

Sarah Premji

MD
Assistant Director, Breast Cancer Research
Sarah Cannon Research Institute

Dr. Sarah Premji joined Sarah Cannon Research Institute as Assistant Director of Breast Cancer Research and Medical Oncologist at Sarah Cannon Research Institute Oncology Partners in September 2025.

Dr. Premji completed medical school at the Medical College of Georgia, residency at Baylor College of Medicine and fellowship at Mayo Clinic. Her research interest is breast oncology therapeutics with a focus on patient reported outcomes and treatment toxicity in clincial trials. She attended the prestigous ASCO/AACR Methods in Clinical Cancer Research, formerly known as Vail Workshop and was awarded a ASCO Concur Cancer Young Investigator Award in 2025. While in fellowship, she was awarded Minnesota Society of Clinical Oncology's "outstanding fellow" award, was recognised at San Antonio Breast Cancer Symposium for a clinical scholar award and received a Mayo Clinic small grant award. Dr. Premji was also awarded scholarships to attend numerous workshops including the Duke Southeastern Fellows Research Retreat, NCCN Oncology Fellows Program, Lynn Sage Symposium, Translational Breast Cancer Research Consortium and Alliance.

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