Constantinos Sofocleous

Dr. Constantinos T. Sofocleous is clinician scientist specializing in interventional oncology, caring for people with cancer. He has been practicing interventional radiology since 1998 and joined the Interventional Radiology Service at Memorial Sloan Kettering in 2002. His expertise include the treatment of primary and metastatic liver and lung cancers using thermal ablation (radiofrequency, microwave, cryoablation) or other non-thermal sources of energy (NanoKnife ® or irreversible electroporation and histotripsy). He also specializes in catheter-directed therapies that treat malignant liver tumors that cannot be removed through surgery or destroyed locally (ablation). He lectures nationally and internationally on topics such as embolization, radio embolization, and ablation of liver tumors — particularly metastases from colorectal cancer in the liver and lungs. His research interest is the assessment, validation, and development of biomarkers and surrogate imaging biomarkers. He was the MSK site primary investigator, of a multi-institutional, RCT Yttrium 90 glass microspheres in addition to standard of care second-line chemotherapy for colorectal liver metastases. He has the Optablate NIH Supported R01 clinical trial. He led the ACCLAIM trial as the global PI. He is currently leading and SIR foundation supported trial to optimize dosimetry for Y90 TARE via post treatment PET guided biopsies. He also explores the immunomodulation effcets of locoregional therapies uisng peripheral and tissue biomrakres. Despite his strong interest in research, Dr. Sofocleous' main focus remains caring for patients.