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Ocular Signs of Dermatologic Conditions: Quick Factsheet for Dermatologists 

The eyes often reveal more than vision-related pathology; they can be key indicators of underlying dermatologic disease. Many cutaneous disorders, such as atopic dermatitis, rosacea, autoimmune blistering diseases, and lupus erythematosus, present with distinctive ocular signs that may precede, mirror, or complicate skin involvement. Early recognition of eyelid, conjunctival, and periocular manifestations is critical to preventing irreversible ocular surface damage, scarring, or vision loss. This factsheet summarizes common ocular signs of dermatologic conditions, highlighting diagnostic clues, affected demographics, and evidence-based treatment options relevant to clinical dermatology practice, serving as a quick-reference guide for dermatologists, ophthalmologists, and multidisciplinary teams managing complex inflammatory skin diseases with ocular involvement. 

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Ocular Signs of Dermatologic Conditions Factsheet 

Presenting Symptoms 

Affected Demographics 

 Diagnosis 

Treatment Options 

Periorbital erythema, scaling, pruritus 

Adults with atopic dermatitis; more common in women and children with chronic eczema¹ 

Clinical diagnosis, may show lichenification and Dennie-Morgan folds, confirm with history of atopy¹ 

Low-potency topical corticosteroids (periocular), topical calcineurin inhibitors (tacrolimus/pimecrolimus), emollients, oral antihistamines² 

Blepharitis with greasy scaling at eyelid margins 

Middle-aged to older adults; associated with seborrheic dermatitis or rosacea³ 

Lid margin erythema/debris, evaluate for scalp/face seborrhea, rule out Demodex³ 

 

Lid hygiene, warm compresses, tea tree oil scrubs, topical metronidazole/ivermectin, systemic tetracyclines for rosacea⁴ 

Xanthelasma palpebrarum (yellow eyelid plaques) 

Adults aged 40 to 60 years; associated with dyslipidemia or familial hypercholesterolemia⁵ 

Fasting lipid profile, biopsy if atypical⁵ 

 

Lipid control, chemical cautery, laser ablation or surgical excision; recurrence possible⁶ 

 

Ocular rosacea (telangiectasia, hyperemia, foreign-body sensation) 

Middle-aged women; often with cutaneous rosacea⁷ 

 

Clinical findings plus slit lamp: telangiectatic lid margin vessels, meibomian gland dysfunction⁷ 

 

Oral doxycycline/minocycline, topical azithromycin, lid hygiene, artificial tears⁸ 

 

 

Conjunctivitis with periocular vesicles or crusting 

Children/adults with atopic dermatitis or eczema herpeticum⁹ 

 

Polymerase chain reaction (PCR) or Tzanck smear for herpes simplex virus (HSV); bilateral involvement common in eczema herpeticum⁹ 

Oral/IV acyclovir; avoid topical corticosteroids during active viral infection¹⁰ 

Lagophthalmos or cicatricial ectropion 

Older adults; sequelae of chronic lupus erythematosus or mucous membrane pemphigoid¹¹ 

Biopsy with direct immunofluorescence for pemphigoid¹¹ 

Systemic corticosteroids, steroid-sparing immunosuppressants (azathioprine, mycophenolate), surgical repair if needed¹² 

Periorbital edema with heliotrope rash 

Middle-aged women; pathognomonic of dermatomyositis¹³ 

Clinical findings plus creatine kinase elevation, electromyography, myositis-specific antibodies¹³ 

 

Systemic corticosteroids, immunosuppressants (methotrexate, azathioprine), strict photoprotection¹⁴ 

Madarosis (loss of eyelashes) 

Chronic blepharitis, discoid lupus, leprosy, alopecia areata¹⁵ 

Directed testing (biopsy for lupus, slit smear for leprosy)¹⁵ 

 

Treat underlying cause; topical or intralesional corticosteroids for alopecia areata¹⁶ 

Conjunctival papillomas/ keratitis 

Immunocompromised individuals; HPV-/HIV-associated¹⁷ 

Slit lamp, histopathology, HPV PCR if indicated¹⁷ 

 

Cryotherapy, topical interferon-α2b; optimize antiretroviral therapy¹⁸ 

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References  

  1. Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment with topical therapies. J Am Acad Dermatol. 2014;71(1):116-132. doi:10.1016/j.jaad.2014.03.023 

  1. Wollenberg A, Barbarot S, Bieber T, et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol. 2018;32(5):657-682. doi:10.1111/jdv.14891 

  1. Lindsley K, Matsumura S, Hatef E, Akpek EK. Interventions for chronic blepharitis. Cochrane Database Syst Rev. 2012;2012(5):CD005556. doi:10.1002/14651858.CD005556.pub2 

  1. van Zuuren EJ, Fedorowicz Z, Tan J, et al. Interventions for rosacea based on the phenotype approach: an updated systematic review including GRADE assessments. Br J Dermatol. 2019;181(1):65-79. doi:10.1111/bjd.17590 

  1. Jain A, Goyal P, Nigam PK, Gurbaksh H, Sharma RC. Xanthelasma palpebrarum—clinical and biochemical profile in a tertiary care hospital of Delhi. Indian J Clin Biochem. 2007;22(2):151-153. doi:10.1007/BF02913335 

  1. Malekzadeh H, Ormseth B, Janis JE. A practical review of the management of Xanthelasma palpebrarum. Plast Reconstr Surg Glob Open. 2023;11(5):e4982. doi:10.1097/GOX.0000000000004982 

  1. Vieira AC, Mannis MJ. Ocular rosacea: common and commonly missed. J Am Acad Dermatol. 2013;69(6 Suppl 1):S36-S41. doi:10.1016/j.jaad.2013.04.042 

  1. Quarterman MJ, Johnson DW, Abele DC, Lesher JL Jr, Hull DS, Davis LS. Ocular rosacea: signs, symptoms, and tear studies before and after treatment with doxycycline. Arch Dermatol. 1997;133(1):49-54. doi:10.1001/archderm.133.1.49 

  1. Wollenberg A, Wetzel S, Burgdorf WHC, Haas J. Viral infections in atopic dermatitis: pathogenic aspects and clinical management. J Allergy Clin Immunol. 2003;112(4):667-674. doi:10.1016/j.jaci.2003.07.001 

  1. Wollenberg A, Zoch C, Wetzel S, Plewig G, Przybilla B. Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases. J Am Acad Dermatol. 2003;49(2):198-205. doi:10.1067/s0190-9622(03)00896-x 

  1. Chan LS, Ahmed AR, Anhalt GJ, et al. The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators. Arch Dermatol. 2002;138(3):370-379. doi:10.1001/archderm.138.3.370 

  1. Schmidt E, Rashid H, Marzano AV, et al. European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology–part II. J Eur Acad Dermatol Venereol. 2021;35(10):1926-1948. doi:10.1111/jdv.17395 

  1. Dalakas MC. Inflammatory muscle diseases. N Engl J Med. 2015;372(18):1734-1747. doi:10.1056/NEJMra1402225 

  1. Aggarwal R, Oddis CV. Therapeutic approaches in myositis. Nat Rev Rheumatol. 2011;13(3):182-191. doi:10.1007/s11926-011-0172-z 

  1. Khong JJ, Casson RJ, Huilgol SC, Selva D. Madarosis. Surv Ophthalmol. 2006;51(6):550-560. doi:10.1016/j.survophthal.2006.08.004 

  1. Alkhalifah A, Alsantali A, Wang E, McElwee KJ, Shapiro J. Alopecia areata update: part II. Treatment. J Am Acad Dermatol. 2010;62(2):191-202. doi:10.1016/j.jaad.2009.10.031 

  1. Ramberg I, Heegaard S. Human papillomavirus related neoplasia of the ocular adnexa. Viruses. 2021;13(8):1522. doi:10.3390/v13081522 

  1. Bolek B, Wylęgała A, Teper S, Kokot J, Wylęgała E. Treatment of conjunctival papilloma with interferon alpha-2b—a case report. Medicine (Baltimore). 2020;99(7):e19181. doi:10.1097/MD.0000000000019181  

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